Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Androgen Deprivation for Prostate Cancer

The beneficial effects of androgen deprivation on prostate cancer have been known for more than a half century, based on work demonstrating the androgen dependency of prostate tumor cells. Androgen deprivation therapy (ADT), initially in the form of bilateral orchiectomy, has accordingly long been a mainstay for the palliation of metastatic prostate cancer. For most of its history, concerns abo...

SPINK1 protein expression and prostate cancer progression.

PURPOSE SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and prostate cancer-specific survival. EXPERIMENTAL DESIGN The study included 879 participants in the U.S. Physicians' Health Study and Health Professionals Follow-Up Study, diagnose...

Androgen deprivation increases p300 expression in prostate cancer cells.

Standard therapy for nonorgan confined prostate cancer aims to block the production or action of androgens. Although initially successful, antiandrogen therapy eventually fails and androgen depletion independent (ADI) disease emerges. Remarkably, ADI prostate cancers still rely on a functional androgen receptor (AR). Aberrant expression of coregulatory proteins required for the formation of pro...

Intermittent androgen deprivation in advanced prostate cancer.

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Androgen Deprivation Therapy for Prostate Cancer